Qualification

BPharm. (UoP, SL), Ph.D. (Chulalongkorn University, TH)

Biography

I earned my Bachelor of Pharmacy (First Class) degree in 2015 from the Faculty of Allied Health Sciences, University of Peradeniya, and completed my PhD in Pharmaceutical Sciences and Technology in 2023 from Chulalongkorn University, Thailand. My research focuses on behavioural pharmacology, specifically using animal models to study pain-like behaviours in rodents and evaluating analgesic agents from bioactive compounds, chemically modified compounds, and nano formulations. I am currently exploring the role of neuroinflammation in pain and the efficacy of nanodrugs in treating both acute and chronic pain.

Qualification

Ph.D. in Pharmaceutical Sciences and Technology (CU, TH)

BPharm. (UoP, SL)

Course/Modules Teaching for undergraduates

• Pharmacology and Toxicology
• Applied Pharmacology
• Bioparmaceutics
• Pharmaceutics
• Cell Biology and Immunology

Research and publications

Present research interests

Neuropharmacology, Behavioral and Molecular Neurobiology of Pain, Drug Discovery and Development, Nano Drug Delivery

Special awards and prizes

• Best Scientific paper award for the abstract, “Influence on tissue concentration of prophylactic antibiotics by timing of application of tourniquet and administration of intravenous prophylactic antibiotics in orthopaedic limb surgeries” in Sri Lanka Orthopaedic Association Annual Academic Sessions (2015)
• 100^th Anniversary Chulalongkorn University Fund for Doctoral Scholarship and Scholarship for International Graduate Students supported by Graduate School, Chulalongkorn University (2018-2023)

Research publications(full paper)

• Hasriadi, H., Wasana, P. W. D., Thongphichai, W., Sukrong, S., & Towiwat, P. (2024). Exploring the safety of lycorine in the central nervous system and its impact on pain-like behaviors in mice. Scientific Reports, 14(1), 16856.
• Jayashan, S. S., Darai, N., Rungrotmongkol, T., Dasuni Wasana, P. W., Nwe, S. Y., Thongphichai, W., ... & Sukrong, S. (2024). Exploring the Therapeutic Potential of Spilanthol from Acmella paniculata (Wall ex DC.) RK Jansen in Attenuating Neurodegenerative Diseases: A Multi-Faceted Approach Integrating In Silico and In Vitro Methodologies. Applied Sciences, 14(9), 3755.
• Hasriadi, Wasana, P. W. D., Thongphichai, W., Samun, Y., Sukrong, S., & Towiwat, P. (2024). Curcuma latifolia Roscoe extract reverses inflammatory pain in mice and offers a favorable CNS safety profile. Journal of Ethnopharmacology, 318, 116877.
• Wasana, P. W. D., Vajragupta, O., Rojsitthisak, P., Towiwat, P., & Rojsitthisak, P. (2023). Metformin and curcumin co-encapsulated chitosan/alginate nanoparticles as effective oral carriers against pain-like behaviors in mice. International Journal of Pharmaceutics, 640, 123037.
• Hasriadi, Wasana, P. W. D., Thongphichai, W., Samun, Y., Sukrong, S., & Towiwat, P. (2024). Curcuma latifolia Roscoe extract reverses inflammatory pain in mice and offers a favorable CNS safety profile. Journal of Ethnopharmacology, 318, 116877.
• Limcharoen, T., Dasuni Wasana, P. W., Hasriadi, Angsuwattana, P., Muangnoi, C., Warinhomhoun, S., ... & Towiwat, P. (2023). An Integrative Approach to Investigate the Mode of Action of (−)-Dendroparishiol in Bacterial Meningitis: Computer-Aided Estimation of Biological Activity and Network Pharmacology. International Journal of Molecular Sciences, 24(9), 8072.
• Dasuni Wasana, P. W., Hasriadi, Muangnoi, C., Vajragupta, O., Rojsitthisak, P., Rojsitthisak, P., & Towiwat, P. (2022). Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain. Scientific Reports, 12(1), 9713.
• Boonrueng, P., Wasana, P. W. D., Hasriadi, Vajragupta, O., Rojsitthisak, P., & Towiwat, P. (2022). Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects. Chinese Medicine, 17(1), 119.
• Hasriadi, Dasuni Wasana, P. W., Suwattananuruk, P., Thompho, S., Thitikornpong, W., Vajragupta, O., ... & Towiwat, P. (2022). Curcumin Diethyl γ-Aminobutyrate, a Prodrug of Curcumin, for Enhanced Treatment of Inflammatory Pain. ACS Pharmacology & Translational Science, 5(9), 774-790.
• Hasriadi, Wasana, P. W. D., Sritularak, B., Vajragupta, O., Rojsitthisak, P., & Towiwat, P. (2022). Batatasin III, a Constituent of Dendrobium scabrilingue, Improves Murine Pain-like Behaviors with a Favorable CNS Safety Profile. Journal of Natural Products, 85(7), 1816-1825.
• Kiratipaiboon, C., Wasana, P. W. D., Hasriadi, Sukrong, S., Ruangrungsri, N., & Towiwat, P. (2022). Herbal root extracts in Ben-Cha-Moon-Yai remedy attenuated pain-like behaviors and inflammation through the opioid and prostaglandin systems. Journal of Ethnopharmacology, 290, 115088.
• Limcharoen, T., Muangnoi, C., Wasana, P. W. D., Vajragupta, O., Rojsitthisak, P., & Towiwat, P. (2021). Improved antiallodynic, antihyperalgesic and anti-inflammatory response achieved through potential prodrug of curcumin, curcumin diethyl diglutarate in a mouse model of neuropathic pain. European journal of pharmacology, 899, 174008.
• Hasriadi, Dasuni Wasana, P. W., Vajragupta, O., Rojsitthisak, P., & Towiwat, P. (2021). Automated home-cage monitoring as a potential measure of sickness behaviors and pain-like behaviors in LPS-treated mice. Plos one, 16(8), e0256706.
• Hasriadi, Wasana, P. W. D., Vajragupta, O., Rojsitthisak, P., & Towiwat, P. (2021). Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain. Scientific Reports, 11(1), 1-16.
• Rivai, B., Hasriadi, Wasana, P. W. D., Chansriniyom, C., Towiwat, P., Punpreuk, Y., Likhitwitayawuid, K., ... & Sritularak, B. (2023). Potential role of a novel biphenanthrene derivative isolated from Aerides falcata in central nervous system diseases. RSC advances, 13(16), 10757-10767.

Membership of professional associations

• Member of Pharmaceutical Society of Sri Lanka Registered Pharmacist in Sri Lanka Medical Council